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Carbamazepine

Carmazepine is an iminostilbene derivative used for the treatment of epilepsy; trigeminal neuralgia; and simple and complex, partial and generalized Convuislive seizures. It is administered either alone or in combination with other antiepileptic drugs. The therapeutic range for carbamazepine is between 4 and 12ug/ Ml. however , individual differences in obsorption and metabolism and can result in highly variable response to carbamazepine. Montioringlevels assiste the physician in optimizing dosage and minimizing toxic side effects for each patient.

Volume required :
20 uL serum or heparinized plasma.

DHEA-SO4

Is important in investigation of abnoramal hair growth (hirsutism) and balding (alopecia) in women. It is also of valu in the assessment of adrenarche and delayed puberty. Accordingly, DHEA-SO4 is ofter assayed in conjunction with free testosterone As an initial screen for hyperandrogenism in hirsutism. High DHEA-SO4 levels are often encountered in the polycystic ovary syndrome, Showing that adrenal hyperandrogenism is a fairly typical facet of this syndrome. Extermely high levels (greater than 700 or 800 ug/dL) in women are suggestive Of a hormone – secreting adrenal tumor. (By contract, DHEA –SO4 levels are typically normalin the presence of ovarian tumors.)

Expected Values :

  • . Range
  • Females 35-430 ug/dL
  • Males 80-560 ug/gL

Limitation

Heterophilic antibodies in human serum can react with the immunoglubulins Included in the assey components causing interference with in vitro immunoassays. Samples from patients routinely exposed to animals or animal serum products can demonstrate this type of interference potentially causing an anomalous result.



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